Formulation and In-vitro Evaluation of Conventional Tablets of Ezetimibe by Using Solid Dispersion

Objective: The objective of the present investigation was to improve dissolution characteristics of EZE, which might offer improved bioavailability. Method: The solid dispersion of Ezetimibe was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, Sodium starch glycolate). The tablets were prepared by direct compression method. The compressed tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content, drug-polymer interactions, in vitro drug release and short term stability studies. Results: The prepared dispersion showed marked increase in the dissolution rate of Ezetimibe than that of pure drug and the in vitro release studies revealed that there was an improvement in the dissolution characteristics of EZE when prepared as solid dispersions. Solid dispersion with SSG and PVPK30 gave better rate and extent of dissolution. The best fit model indicating the probable mechanism of drug release from solid dispersions was found to be first order. The results of characterization of solid dispersions by Fourier transform infrared spectroscopy revealed that there is no chemical interaction between drug and polymers. Conclusion: It can be concluded that the solid dispersions prepared with SSG has high solubility than PVP K30 and among all the formulations, F6 has highest solubility and in vitro dissolution rate.